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What Happens When You Withdraw From Opioids?

Withdrawal from opioids can be an uncomfortable and sometimes painful experience. The severity of symptoms varies depending on factors such as the type of opioid used, duration of use, and individual differences in metabolism and tolerance. During withdrawal, the body is essentially trying to readjust and function without the substance it has become accustomed to.
woman sitting in a chair and holding a emotions pillow in group therapy at Crestview Recovery

What are Opioid Withdrawal Symptoms?

Opioid withdrawal symptoms can range from mild to severe. The severity is often related to the amount and frequency of opioid use. Common symptoms include:

  • Nausea and vomiting
  • Diarrhea
  • Stomach cramps
  • Muscle aches and pains
  • Restlessness or irritability
  • Anxiety or agitation
  • Insomnia or difficulty sleeping
  • Excessive sweating
  • Runny nose and watery eyes
  • Goosebumps or chills

As the body adjusts to the absence of opioids, these symptoms may intensify before gradually improving. In some cases, individuals may also experience more severe symptoms such as hallucinations, seizures, high blood pressure, dilated pupils, and rapid heartbeat. Find opioid addiction treatment at our residential rehab in Portland. We help people quit drug use and teach strategies for relapse prevention.

Opioid Withdrawal Timeline

The opioid withdrawal timeline can vary from person to person, but generally follows a similar pattern. Withdrawal symptoms can begin as soon as a few hours after the last use and peak within 2–3 days. However, some symptoms may linger for weeks or even months.

The first few days after stopping or reducing opioid use are often the most intense. Symptoms usually start within 12 hours and peak around 72 hours after the last use. This period, known as acute withdrawal, may include flu-like symptoms such as nausea, vomiting, diarrhea, sweating, agitation, and muscle aches.

As the acute withdrawal period ends, symptoms may start to improve but can still be uncomfortable. Many individuals report feeling restless and anxious and having difficulty sleeping during this stage.

By the end of the first week, most physical symptoms have subsided or significantly decreased. However, psychological symptoms such as anxiety and depression may persist for longer periods.

Symptoms may continue to improve over the following weeks. However, some individuals may experience lingering symptoms such as fatigue, anxiety, and depression for several months.

Heroin Withdrawal

Heroin is a highly potent and addictive opioid. Due to its potency, withdrawal symptoms can be more severe compared to other opioids. In addition to the common symptoms, individuals withdrawing from heroin may also experience intense cravings for the drug, severe muscle spasms, rapid heart rate, and high blood pressure. Crestview Recovery offers heroin addiction treatment for those struggling with heroin use.

Fentanyl Withdrawal

Fentanyl is a synthetic opioid that is many times more potent than heroin. Withdrawal from fentanyl can be even more challenging and dangerous. Along with the common symptoms, individuals withdrawing from fentanyl may also experience difficulty breathing, confusion and disorientation, and seizures. It’s essential to seek medical assistance when withdrawing from fentanyl. We offer fentanyl addiction treatment to assist you.

Kratom Withdrawal

Kratom contains opioid-like compounds, making it potentially addictive and leading to withdrawal symptoms when stopped abruptly. Common symptoms of kratom withdrawal include runny nose and watery eyes, mood swings and irritability, insomnia and restlessness, and muscle cramps and pains.

How Long Do Opioids Last in Your System?

The duration that opioids stay in your system can vary based on several factors, including the specific type of opioid, dosage, frequency of use, and metabolism.

  • Urine Test: typically detectable for 1 to 3 days after the last use (methadone and buprenorphine may be detected longer)
  • Blood Test: usually detectable for up to 24 hours
  • Saliva Test: detectable for 1 to 4 days
  • Hair Test: detectable for up to 90 days
group discussing opioid withdrawal symptoms during therapy

Can You Stop Using Opioids By Yourself?

While it is possible to stop using opioids on your own, it is not recommended. Withdrawal symptoms can be severe and may require medical intervention or support from a rehabilitation program. It’s essential to seek help from a healthcare professional or addiction specialist when attempting to quit opioids. They can provide guidance, support, and addiction resources to make the process as safe and comfortable as possible.

Opioid Addiction Treatment: Residential Care and Medication-Assisted Treatment

Overcoming opioid addiction requires more than willpower; it takes a structured, clinically supported approach that addresses both the physical and psychological dimensions of dependence. At Crestview Recovery in Portland, Oregon, we provide comprehensive opioid addiction treatment through residential care and medication-assisted treatment (MAT), giving individuals the tools and support they need to achieve lasting recovery.

Our residential treatment program provides 24/7 care in a structured, supportive environment. Removing yourself from the triggers and stressors of daily life allows you to focus entirely on recovery. Clients in our residential program engage in daily individual and group therapy, build life skills, and work closely with our clinical team to develop a personalized recovery plan. For those who need an extended level of support, our 90-day treatment program offers additional time to stabilize and build a strong foundation for sobriety.

Medication-assisted treatment combines FDA-approved medications with therapy and counseling to treat opioid use disorder. MAT reduces withdrawal symptoms and cravings, making it significantly easier to engage with and benefit from the therapeutic work of recovery. Commonly used medications include:

  • Methadone: a long-acting opioid that reduces withdrawal symptoms and cravings
  • Buprenorphine: helps ease withdrawal symptoms and suppress cravings
  • Naltrexone: blocks opioid receptors to reduce the rewarding effects of opioids and support sustained sobriety
  • Clonidine: manages physical symptoms such as anxiety, agitation, and muscle aches during early recovery

Therapy for Opioid Addiction

Therapy is a cornerstone of opioid addiction treatment. Working with a therapist helps individuals uncover the underlying causes of their addiction, build healthier coping skills, and develop a concrete plan for preventing relapse. At Crestview Recovery, we offer a range of evidence-based therapies tailored to each person’s needs, including:

two couples with therapist engaged in family therapy program discussion

Self-Care During Opioid Withdrawal

  • Stay hydrated by drinking plenty of water
  • Eat nutritious meals to provide your body with the energy it needs
  • Get adequate rest and sleep to help your body recover
  • Engage in gentle physical activity, such as walking or yoga, to improve mood and reduce muscle aches
  • Practice relaxation techniques, such as deep breathing or meditation, to manage anxiety and stress
  • Seek support from loved ones or a support group to help you through this challenging time

Opioid Addiction Treatment in Portland

At Crestview Recovery, we understand the challenges of opioid withdrawal and addiction. We offer comprehensive treatment programs that address each individual’s unique needs, providing them with the tools and support necessary to achieve lasting recovery. If you or a loved one is struggling with opioid addiction, contact us today to learn more about our evidence-based treatment options.

Opioid Withdrawal FAQ

The specific opioid involved significantly shapes the withdrawal experience. Short-acting opioids like heroin cause withdrawal symptoms to begin within hours and resolve more quickly.

Longer-acting opioids such as methadone may delay the onset of symptoms by a day or more but can produce a prolonged withdrawal that stretches over several weeks. Synthetic opioids like fentanyl, due to their potency, can produce particularly intense withdrawal. Your individual history matters too. Crestview’s clinical team conducts thorough assessments to account for these differences.

Withdrawal refers to the symptoms the body produces when opioid use stops. Detox is the supervised medical process of managing those symptoms safely. Detox is not treatment on its own; it’s a first step. Long-term recovery from opioid addiction requires follow-up care, including therapy, relapse prevention planning, and peer support, which Crestview Recovery provides through a full continuum of programs.

Yes. Medications like buprenorphine, methadone, and clonidine can help reduce the severity of withdrawal symptoms and cravings. These are part of a broader approach called medication-assisted treatment (MAT), which combines pharmacological support with behavioral therapies. MAT is supervised by medical professionals and has strong evidence behind it as part of comprehensive opioid addiction treatment.

Physical symptoms of opioid withdrawal typically peak within 2–3 days and subside within a week. Psychological symptoms, including anxiety, depression, irritability, and cravings, often take longer to resolve and can persist for weeks or even months. This is sometimes referred to as post-acute withdrawal syndrome (PAWS). Ongoing therapy through individual counseling, DBT, or group therapy plays a key role in working through this phase.

Stopping opioid use abruptly without medical supervision is not recommended. While opioid withdrawal is rarely fatal on its own, severe dehydration, cardiovascular stress, and the intense discomfort of withdrawal dramatically increase the risk of relapse, which is when overdose risk is highest, as tolerance drops quickly. A medically supervised approach protects both safety and long-term outcomes.

Having family involved in recovery can meaningfully improve outcomes. Family members can provide encouragement, help identify warning signs of relapse, and learn how to support without enabling. Crestview Recovery offers family therapy as part of the treatment process to help rebuild trust and communication while equipping loved ones with practical tools.

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Opioid Withdrawal Symptoms and Timeline

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